Drug interactions
Bretylium + Hydrochlorothiazide-valsartan
Severity: Moderate
Bretylium and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium frequently causes hypotension, and combining it with a diuretic and an angiotensin receptor blocker can magnify this effect. Volume depletion from the thiazide may make hypotension more pronounced.
What this interaction means in plain words
Bretylium and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects via adrenergic neuron blockade plus diuresis and renin-angiotensin blockade.
What to do
Monitor blood pressure continuously during bretylium use and consider temporarily holding or reducing the antihypertensives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Bretylium with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Bretylium and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium frequently causes hypotension, and combining it with a diuretic and an angiotensin receptor blocker can magnify this effect. Volume depletion from the thiazide may make hypotension more pronounced.
How serious is the interaction between Bretylium and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during bretylium use and consider temporarily holding or reducing the antihypertensives.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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