Drug interactions
Bretylium + Isosorbide dinitrate
Severity: Moderate
Bretylium and Isosorbide dinitrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower blood pressure, and bretylium impairs sympathetic reflex compensation. Together with a nitrate they may cause pronounced or orthostatic hypotension.
What this interaction means in plain words
Bretylium and Isosorbide dinitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects of nitrate vasodilation and bretylium adrenergic neuron blockade.
What to do
Monitor blood pressure and heart rate, particularly after dose changes. Counsel patients to rise slowly and correct volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Frequently asked questions
Can I take Bretylium with Isosorbide dinitrate?
MediHelp rates the interaction as moderate. Bretylium and Isosorbide dinitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower blood pressure, and bretylium impairs sympathetic reflex compensation. Together with a nitrate they may cause pronounced or orthostatic hypotension.
How serious is the interaction between Bretylium and Isosorbide dinitrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly after dose changes. Counsel patients to rise slowly and correct volume depletion.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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