Drug interactions
Bretylium + Lisinopril
Severity: Moderate
Bretylium and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium commonly causes hypotension through adrenergic neuron blockade. Combined with lisinopril, hypotension may be more pronounced.
What this interaction means in plain words
Bretylium and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from sympathetic blockade and ACE inhibition.
What to do
Monitor blood pressure continuously during bretylium use and reduce or hold lisinopril if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Bretylium with Lisinopril?
MediHelp rates the interaction as moderate. Bretylium and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium commonly causes hypotension through adrenergic neuron blockade. Combined with lisinopril, hypotension may be more pronounced.
How serious is the interaction between Bretylium and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during bretylium use and reduce or hold lisinopril if hypotension develops.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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