Drug interactions
Bretylium + Rasagiline
Severity: Moderate
Bretylium and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium causes release of norepinephrine from sympathetic nerve endings, and MAO inhibition can potentiate this effect. The result may be hypertension, tachycardia or arrhythmias.
What this interaction means in plain words
Bretylium and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibition reduces catecholamine breakdown, amplifying the norepinephrine released by bretylium.
What to do
Monitor blood pressure and heart rhythm closely if both are required. Consider an alternative antiarrhythmic if pressor responses occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Bretylium with Rasagiline?
MediHelp rates the interaction as moderate. Bretylium and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium causes release of norepinephrine from sympathetic nerve endings, and MAO inhibition can potentiate this effect. The result may be hypertension, tachycardia or arrhythmias.
How serious is the interaction between Bretylium and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rhythm closely if both are required. Consider an alternative antiarrhythmic if pressor responses occur.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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