Drug interactions
Bretylium + Spironolactone
Severity: Moderate
Bretylium and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium frequently causes hypotension through adrenergic neuron blockade, and spironolactone may add to blood pressure lowering. The combination may increase the risk of significant hypotension.
What this interaction means in plain words
Bretylium and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects: sympathetic neuron blockade plus diuretic-mediated volume reduction.
What to do
Monitor blood pressure closely during bretylium therapy and reduce or hold spironolactone if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Bretylium with Spironolactone?
MediHelp rates the interaction as moderate. Bretylium and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium frequently causes hypotension through adrenergic neuron blockade, and spironolactone may add to blood pressure lowering. The combination may increase the risk of significant hypotension.
How serious is the interaction between Bretylium and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during bretylium therapy and reduce or hold spironolactone if hypotension develops.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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