Drug interactions
Bretylium + Triamterene
Severity: Moderate
Bretylium and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium frequently causes hypotension by blocking adrenergic neuron release of norepinephrine. Triamterene's diuretic and blood pressure-lowering effects may add to this.
What this interaction means in plain words
Bretylium and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from adrenergic neuron blockade and diuretic-induced volume depletion.
What to do
Monitor blood pressure and volume status closely during bretylium therapy. Consider holding or reducing triamterene if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Bretylium with Triamterene?
MediHelp rates the interaction as moderate. Bretylium and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium frequently causes hypotension by blocking adrenergic neuron release of norepinephrine. Triamterene's diuretic and blood pressure-lowering effects may add to this.
How serious is the interaction between Bretylium and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and volume status closely during bretylium therapy. Consider holding or reducing triamterene if hypotension occurs.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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