Drug interactions
Bretylium + Valsartan
Severity: Moderate
Bretylium and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium frequently causes hypotension through adrenergic neuron blockade, and valsartan adds to blood pressure lowering. The combination may produce excessive hypotension, particularly in volume-depleted patients.
What this interaction means in plain words
Bretylium and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from sympathetic neuron blockade and angiotensin II receptor antagonism.
What to do
Monitor blood pressure continuously during bretylium use and reduce or hold valsartan if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Bretylium with Valsartan?
MediHelp rates the interaction as moderate. Bretylium and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium frequently causes hypotension through adrenergic neuron blockade, and valsartan adds to blood pressure lowering. The combination may produce excessive hypotension, particularly in volume-depleted patients.
How serious is the interaction between Bretylium and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during bretylium use and reduce or hold valsartan if hypotension develops.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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