Drug interactions
Brexanolone + Chlorpheniramine
Severity: Major
Brexanolone and Chlorpheniramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes excessive sedation and sudden loss of consciousness, and CNS depressants such as chlorpheniramine may add to this risk.
What this interaction means in plain words
Brexanolone and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression via GABA-A modulation and H1 antagonism.
What to do
Monitor sedation and oxygen saturation continuously during the infusion. Hold the antihistamine or reduce the brexanolone dose if sedation occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlorpheniramine
- Belladonna and opium + Chlorpheniramine Major
- Benzhydrocodone / acetaminophen + Chlorpheniramine Major
- Buprenorphine long-acting + Chlorpheniramine Major
- Buprenorphine subdermal implant + Chlorpheniramine Major
- Buprenorphine transdermal + Chlorpheniramine Major
- Calcium / magnesium / potassium / sodium oxybates + Chlorpheniramine Major
Frequently asked questions
Can I take Brexanolone with Chlorpheniramine?
MediHelp rates the interaction as major. Brexanolone and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone causes excessive sedation and sudden loss of consciousness, and CNS depressants such as chlorpheniramine may add to this risk.
How serious is the interaction between Brexanolone and Chlorpheniramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and oxygen saturation continuously during the infusion. Hold the antihistamine or reduce the brexanolone dose if sedation occurs.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Buprenorphine long-acting. The full list is on the Chlorpheniramine page.
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