Drug interactions
Brexanolone + Eszopiclone
Severity: Major
Brexanolone and Eszopiclone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes excessive sedation and sudden loss of consciousness in some patients, and eszopiclone adds further CNS depression. The risk of oversedation is increased when they are used together.
What this interaction means in plain words
Brexanolone and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression via positive allosteric modulation of GABA-A receptors by both drugs.
What to do
Monitor continuously for sedation and hypoxia during the infusion, as required for brexanolone. Hold or reduce eszopiclone and the brexanolone infusion if excessive sedation occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eszopiclone
- Calcium / magnesium / potassium / sodium oxybates + Eszopiclone Contraindicated
- Eszopiclone + Sodium oxybate Contraindicated
- Amobarbital + Eszopiclone Major
- Benzhydrocodone / acetaminophen + Eszopiclone Major
- Buprenorphine long-acting + Eszopiclone Major
- Buprenorphine subdermal implant + Eszopiclone Major
Frequently asked questions
Can I take Brexanolone with Eszopiclone?
MediHelp rates the interaction as major. Brexanolone and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone causes excessive sedation and sudden loss of consciousness in some patients, and eszopiclone adds further CNS depression. The risk of oversedation is increased when they are used together.
How serious is the interaction between Brexanolone and Eszopiclone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor continuously for sedation and hypoxia during the infusion, as required for brexanolone. Hold or reduce eszopiclone and the brexanolone infusion if excessive sedation occurs.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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