Drug interactions
Buprenorphine long-acting + Eszopiclone
Severity: Major
Buprenorphine long-acting and Eszopiclone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid such as buprenorphine with a sedative-hypnotic raises the risk of profound sedation, respiratory depression, coma and death. Long-acting injection formulations cannot be quickly withdrawn if problems arise.
What this interaction means in plain words
Buprenorphine long-acting and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid receptor agonism plus GABA-A potentiation.
What to do
Avoid the combination where possible, or limit eszopiclone dose and duration. Monitor for sedation and respiratory depression, and counsel the patient and caregivers.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eszopiclone
Frequently asked questions
Can I take Buprenorphine long-acting with Eszopiclone?
MediHelp rates the interaction as major. Buprenorphine long-acting and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid such as buprenorphine with a sedative-hypnotic raises the risk of profound sedation, respiratory depression, coma and death. Long-acting injection formulations cannot be quickly withdrawn if problems arise.
How serious is the interaction between Buprenorphine long-acting and Eszopiclone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or limit eszopiclone dose and duration. Monitor for sedation and respiratory depression, and counsel the patient and caregivers.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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