Drug interactions
Brexanolone + Isoflurane
Severity: Moderate
Brexanolone and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes excessive sedation and sudden loss of consciousness, and a general anesthetic adds to CNS depression. Respiratory depression and prolonged sedation are possible.
What this interaction means in plain words
Brexanolone and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A-mediated CNS depression.
What to do
Avoid giving brexanolone around anesthesia where possible. If both are needed, monitor sedation level and oxygen saturation continuously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Frequently asked questions
Can I take Brexanolone with Isoflurane?
MediHelp rates the interaction as moderate. Brexanolone and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone causes excessive sedation and sudden loss of consciousness, and a general anesthetic adds to CNS depression. Respiratory depression and prolonged sedation are possible.
How serious is the interaction between Brexanolone and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving brexanolone around anesthesia where possible. If both are needed, monitor sedation level and oxygen saturation continuously.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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