Drug interactions
Bedaquiline + Isoflurane
Severity: Major
Bedaquiline and Isoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline prolongs the QT interval, and its long terminal half-life means the effect continues for months. Isoflurane may add to repolarization delay and raise the risk of torsades de pointes.
What this interaction means in plain words
Bedaquiline and Isoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Isoflurane belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Obtain an ECG and correct potassium, magnesium and calcium before anesthesia. Monitor the ECG continuously and consider the choice of anesthetic and other QT-prolonging drugs carefully.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isoflurane
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Isoflurane?
MediHelp rates the interaction as major. Bedaquiline and Isoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bedaquiline prolongs the QT interval, and its long terminal half-life means the effect continues for months. Isoflurane may add to repolarization delay and raise the risk of torsades de pointes.
How serious is the interaction between Bedaquiline and Isoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct potassium, magnesium and calcium before anesthesia. Monitor the ECG continuously and consider the choice of anesthetic and other QT-prolonging drugs carefully.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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