Drug interactions
Brexanolone + Nalbuphine
Severity: Major
Brexanolone and Nalbuphine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes excessive sedation and sudden loss of consciousness, and nalbuphine adds opioid-related central nervous system depression. Together they raise the likelihood of profound sedation and respiratory depression.
What this interaction means in plain words
Brexanolone and Nalbuphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression through GABA-A positive modulation by brexanolone and opioid receptor activity of nalbuphine.
What to do
Monitor sedation level and pulse oximetry continuously during the brexanolone infusion. Reduce or hold the nalbuphine dose if excessive sedation occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Butabarbital + Nalbuphine Major
Frequently asked questions
Can I take Brexanolone with Nalbuphine?
MediHelp rates the interaction as major. Brexanolone and Nalbuphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone causes excessive sedation and sudden loss of consciousness, and nalbuphine adds opioid-related central nervous system depression. Together they raise the likelihood of profound sedation and respiratory depression.
How serious is the interaction between Brexanolone and Nalbuphine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and pulse oximetry continuously during the brexanolone infusion. Reduce or hold the nalbuphine dose if excessive sedation occurs.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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