Drug interactions
Brexanolone + Orphenadrin
Severity: Major
Brexanolone and Orphenadrin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes excessive sedation and sudden loss of consciousness, and orphenadrine can add to CNS depression. The combination raises the risk of profound sedation during and after the infusion.
What this interaction means in plain words
Brexanolone and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression via GABA-A modulation (brexanolone) and sedating anticholinergic effects (orphenadrine).
What to do
Monitor continuously with pulse oximetry during the infusion. Consider withholding orphenadrine during infusion or reducing its dose if sedation occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Orphenadrin
Frequently asked questions
Can I take Brexanolone with Orphenadrin?
MediHelp rates the interaction as major. Brexanolone and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone causes excessive sedation and sudden loss of consciousness, and orphenadrine can add to CNS depression. The combination raises the risk of profound sedation during and after the infusion.
How serious is the interaction between Brexanolone and Orphenadrin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor continuously with pulse oximetry during the infusion. Consider withholding orphenadrine during infusion or reducing its dose if sedation occurs.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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