Drug interactions
Brexanolone + Pimavanserin
Severity: Moderate
Brexanolone and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes dose-related sedation and excessive sleepiness, and pimavanserin can also cause somnolence. Used together, additive CNS depression may impair alertness and, rarely, lead to loss of consciousness.
What this interaction means in plain words
Brexanolone and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor sedation level and pulse oximetry during the brexanolone infusion, and interrupt or reduce the infusion if excessive sedation occurs. Advise patients not to drive or operate machinery until sedation has resolved.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Brexanolone with Pimavanserin?
MediHelp rates the interaction as moderate. Brexanolone and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone causes dose-related sedation and excessive sleepiness, and pimavanserin can also cause somnolence. Used together, additive CNS depression may impair alertness and, rarely, lead to loss of consciousness.
How serious is the interaction between Brexanolone and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and pulse oximetry during the brexanolone infusion, and interrupt or reduce the infusion if excessive sedation occurs. Advise patients not to drive or operate machinery until sedation has resolved.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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