Drug interactions
Pimavanserin + Vandetanib
Severity: Contraindicated
Pimavanserin and Vandetanib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib carries a boxed warning for QT prolongation, torsades de pointes and sudden death. Adding pimavanserin increases the arrhythmia risk.
What this interaction means in plain words
Pimavanserin and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pimavanserin belongs to Central Nervous System; Vandetanib belongs to Oncology.
Why it happens
Additive QTc prolongation.
What to do
Avoid the combination; labeling advises against vandetanib with other QT-prolonging drugs. Use an alternative to one of the agents.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
- Amobarbital + Pimavanserin Major
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Pimavanserin with Vandetanib?
MediHelp rates the interaction as contraindicated. Pimavanserin and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib carries a boxed warning for QT prolongation, torsades de pointes and sudden death. Adding pimavanserin increases the arrhythmia risk.
How serious is the interaction between Pimavanserin and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; labeling advises against vandetanib with other QT-prolonging drugs. Use an alternative to one of the agents.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Adagrasib. The full list is on the Pimavanserin page.
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