Drug interactions
Brimonidine + Buprenorphine long-acting
Severity: Moderate
Brimonidine and Buprenorphine long-acting: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist that can cause drowsiness and CNS depression through systemic absorption. Combined with long-acting injectable buprenorphine, sedation may be increased, though ophthalmic dosing carries limited systemic exposure.
What this interaction means in plain words
Brimonidine and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from alpha-2 adrenergic agonism and opioid receptor agonism.
What to do
Monitor sedation level and respiratory status, particularly in children, older adults and those with respiratory disease. Counsel on additive drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Buprenorphine long-acting?
MediHelp rates the interaction as moderate. Brimonidine and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brimonidine is an alpha-2 agonist that can cause drowsiness and CNS depression through systemic absorption. Combined with long-acting injectable buprenorphine, sedation may be increased, though ophthalmic dosing carries limited systemic exposure.
How serious is the interaction between Brimonidine and Buprenorphine long-acting?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status, particularly in children, older adults and those with respiratory disease. Counsel on additive drowsiness.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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