Drug interactions
Brimonidine + Butorphanol
Severity: Minor
Brimonidine and Butorphanol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist that can cause drowsiness and lower blood pressure. Systemic absorption from eye drops is limited, so the effect with an opioid is usually small.
What this interaction means in plain words
Brimonidine and Butorphanol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Butorphanol belongs to Musculoskeletal.
Why it happens
Possible additive CNS depression from alpha-2 agonism and opioid activity after systemic absorption.
What to do
No routine change is needed; watch for unusual drowsiness, especially in children and older adults.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Butorphanol?
MediHelp rates the interaction as minor. Brimonidine and Butorphanol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an alpha-2 agonist that can cause drowsiness and lower blood pressure. Systemic absorption from eye drops is limited, so the effect with an opioid is usually small.
How serious is the interaction between Brimonidine and Butorphanol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; watch for unusual drowsiness, especially in children and older adults.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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