Drug interactions
Brimonidine + Captopril
Severity: Minor
Brimonidine and Captopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine, an alpha-2 agonist, can be absorbed systemically from eye drops and lower blood pressure modestly. Additive hypotension with captopril is possible but usually small.
What this interaction means in plain words
Brimonidine and Captopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Captopril belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from central alpha-2 agonism and ACE inhibition.
What to do
Monitor blood pressure if the patient develops dizziness or fatigue after starting brimonidine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Captopril?
MediHelp rates the interaction as minor. Brimonidine and Captopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine, an alpha-2 agonist, can be absorbed systemically from eye drops and lower blood pressure modestly. Additive hypotension with captopril is possible but usually small.
How serious is the interaction between Brimonidine and Captopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if the patient develops dizziness or fatigue after starting brimonidine.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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