Drug interactions
Brimonidine + Carbidopa-entacapone-levodopa
Severity: Minor
Brimonidine and Carbidopa-entacapone-levodopa: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed brimonidine can cause drowsiness and lower blood pressure, but ophthalmic use gives low exposure. Any additive sedation or hypotension with levodopa-containing therapy is expected to be small.
What this interaction means in plain words
Brimonidine and Carbidopa-entacapone-levodopa have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Carbidopa-entacapone-levodopa belongs to Central Nervous System.
Why it happens
Possible additive central depressant and hypotensive effects via alpha-2 agonism.
What to do
No routine action is needed; counsel patients about drowsiness and dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Carbidopa-entacapone-levodopa?
MediHelp rates the interaction as minor. Brimonidine and Carbidopa-entacapone-levodopa have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemically absorbed brimonidine can cause drowsiness and lower blood pressure, but ophthalmic use gives low exposure. Any additive sedation or hypotension with levodopa-containing therapy is expected to be small.
How serious is the interaction between Brimonidine and Carbidopa-entacapone-levodopa?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; counsel patients about drowsiness and dizziness.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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