Drug interactions
Brimonidine + Lamotrigine
Severity: Minor
Brimonidine and Lamotrigine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine, particularly when absorbed systemically, can cause drowsiness and fatigue. Lamotrigine may add to this effect, but the ophthalmic exposure is small so any additive sedation is likely mild.
What this interaction means in plain words
Brimonidine and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Lamotrigine belongs to Central Nervous System.
Why it happens
Possible additive CNS depression; systemic brimonidine exposure from eye drops is low.
What to do
No routine change is needed. Warn patients about possible drowsiness and review if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lamotrigine
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Lamotrigine?
MediHelp rates the interaction as minor. Brimonidine and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine, particularly when absorbed systemically, can cause drowsiness and fatigue. Lamotrigine may add to this effect, but the ophthalmic exposure is small so any additive sedation is likely mild.
How serious is the interaction between Brimonidine and Lamotrigine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Warn patients about possible drowsiness and review if excessive sedation occurs.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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