Drug interactions
Brimonidine + Loxapine inhaled
Severity: Minor
Brimonidine and Loxapine inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can depress the central nervous system, so sedation may be increased when inhaled loxapine is given to a patient using brimonidine. Systemic brimonidine exposure from eye drops is low, so the effect is generally small.
What this interaction means in plain words
Brimonidine and Loxapine inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depression from alpha-2 agonism and dopamine and serotonin antagonism by loxapine.
What to do
Observe the patient for excess sedation after loxapine inhalation. Advise against driving or hazardous tasks until sedation has resolved.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Loxapine inhaled?
MediHelp rates the interaction as minor. Brimonidine and Loxapine inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can depress the central nervous system, so sedation may be increased when inhaled loxapine is given to a patient using brimonidine. Systemic brimonidine exposure from eye drops is low, so the effect is generally small.
How serious is the interaction between Brimonidine and Loxapine inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe the patient for excess sedation after loxapine inhalation. Advise against driving or hazardous tasks until sedation has resolved.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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