Drug interactions
Brimonidine + Papaveretum
Severity: Minor
Brimonidine and Papaveretum: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum is an opioid mixture that causes sedation and respiratory depression, and brimonidine can add drowsiness. With ophthalmic use systemic brimonidine levels are low, so the added effect is usually small.
What this interaction means in plain words
Brimonidine and Papaveretum have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depression from alpha-2 agonism and opioid receptor agonism.
What to do
Monitor sedation and respiratory rate when papaveretum is given to a patient using brimonidine. Reduce the opioid dose if excessive drowsiness occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Papaveretum?
MediHelp rates the interaction as minor. Brimonidine and Papaveretum have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Papaveretum is an opioid mixture that causes sedation and respiratory depression, and brimonidine can add drowsiness. With ophthalmic use systemic brimonidine levels are low, so the added effect is usually small.
How serious is the interaction between Brimonidine and Papaveretum?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate when papaveretum is given to a patient using brimonidine. Reduce the opioid dose if excessive drowsiness occurs.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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