Drug interactions
Brimonidine + Perindopril
Severity: Minor
Brimonidine and Perindopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an ophthalmic alpha-2 agonist with modest systemic absorption and can occasionally lower blood pressure. Additive hypotension with perindopril is possible but is rarely significant.
What this interaction means in plain words
Brimonidine and Perindopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Perindopril belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from central alpha-2 agonism with ACE inhibition.
What to do
No routine action is required; ask about dizziness and check blood pressure if symptoms occur after starting brimonidine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Perindopril?
MediHelp rates the interaction as minor. Brimonidine and Perindopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an ophthalmic alpha-2 agonist with modest systemic absorption and can occasionally lower blood pressure. Additive hypotension with perindopril is possible but is rarely significant.
How serious is the interaction between Brimonidine and Perindopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required; ask about dizziness and check blood pressure if symptoms occur after starting brimonidine.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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