Drug interactions
Brimonidine + Sacubitril / valsartan
Severity: Minor
Brimonidine and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sacubitril/valsartan lowers blood pressure. Brimonidine can cause hypotension when systemically absorbed, so additive effects are possible, though modest with eye drops.
What this interaction means in plain words
Brimonidine and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypotensive effects from angiotensin receptor blockade with neprilysin inhibition and central alpha-2 agonism.
What to do
Monitor blood pressure and symptoms of hypotension, especially at initiation or dose titration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Brimonidine and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sacubitril/valsartan lowers blood pressure. Brimonidine can cause hypotension when systemically absorbed, so additive effects are possible, though modest with eye drops.
How serious is the interaction between Brimonidine and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension, especially at initiation or dose titration.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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