Drug interactions
Brimonidine + Selegiline transdermal
Severity: Moderate
Brimonidine and Selegiline transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist, and the labeling for MAO inhibitors advises against using such agents together because of possible effects on blood pressure and central activity. Systemic absorption from ophthalmic brimonidine is low, but the combination is cautioned.
What this interaction means in plain words
Brimonidine and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism is not firmly established; possible altered catecholamine handling with MAO inhibition and alpha-2 agonist action.
What to do
Monitor blood pressure and heart rate if the combination is used. Consider an alternative glaucoma agent if hemodynamic changes occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Selegiline transdermal?
MediHelp rates the interaction as moderate. Brimonidine and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brimonidine is an alpha-2 agonist, and the labeling for MAO inhibitors advises against using such agents together because of possible effects on blood pressure and central activity. Systemic absorption from ophthalmic brimonidine is low, but the combination is cautioned.
How serious is the interaction between Brimonidine and Selegiline transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate if the combination is used. Consider an alternative glaucoma agent if hemodynamic changes occur.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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