Drug interactions
Brimonidine + Sufentanil sl
Severity: Moderate
Brimonidine and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sublingual sufentanil produces opioid-related sedation and respiratory depression, and brimonidine can add drowsiness through central alpha-2 agonism. Systemic brimonidine exposure from eye drops is small, so the effect is likely modest but possible.
What this interaction means in plain words
Brimonidine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from alpha-2 adrenergic agonism and opioid receptor agonism.
What to do
Observe for excessive sedation and slowed breathing after sublingual sufentanil doses in patients on brimonidine, and counsel against driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Sufentanil sl?
MediHelp rates the interaction as moderate. Brimonidine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sublingual sufentanil produces opioid-related sedation and respiratory depression, and brimonidine can add drowsiness through central alpha-2 agonism. Systemic brimonidine exposure from eye drops is small, so the effect is likely modest but possible.
How serious is the interaction between Brimonidine and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe for excessive sedation and slowed breathing after sublingual sufentanil doses in patients on brimonidine, and counsel against driving or operating machinery.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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