Drug interactions
Brimonidine + Thiothixene
Severity: Moderate
Brimonidine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is an antipsychotic with sedative properties, and brimonidine can cause drowsiness. Together they may produce additive sedation and, with significant systemic brimonidine absorption, hypotension.
What this interaction means in plain words
Brimonidine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and possible additive hypotension from antipsychotic antagonism of histamine and alpha-1 receptors plus central alpha-2 agonism.
What to do
Monitor for sedation and orthostatic symptoms, and adjust the antipsychotic dose if excessive drowsiness develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Thiothixene?
MediHelp rates the interaction as moderate. Brimonidine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene is an antipsychotic with sedative properties, and brimonidine can cause drowsiness. Together they may produce additive sedation and, with significant systemic brimonidine absorption, hypotension.
How serious is the interaction between Brimonidine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic symptoms, and adjust the antipsychotic dose if excessive drowsiness develops.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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