Drug interactions
Brimonidine + Triazolam
Severity: Moderate
Brimonidine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam is a short-acting benzodiazepine hypnotic with marked sedative and amnestic effects. Brimonidine can add drowsiness, so psychomotor impairment may be increased.
What this interaction means in plain words
Brimonidine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and central alpha-2 adrenergic agonism.
What to do
Monitor for excessive sedation and next-day impairment, and keep triazolam at the lowest effective dose, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Triazolam?
MediHelp rates the interaction as moderate. Brimonidine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triazolam is a short-acting benzodiazepine hypnotic with marked sedative and amnestic effects. Brimonidine can add drowsiness, so psychomotor impairment may be increased.
How serious is the interaction between Brimonidine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and next-day impairment, and keep triazolam at the lowest effective dose, especially in older patients.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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