Drug interactions
Brimonidine + Triclofos
Severity: Minor
Brimonidine and Triclofos: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic, and brimonidine can cause drowsiness, so sedation may be somewhat increased. Systemic exposure from eye drops is low, so the effect is usually small, though children are more sensitive to brimonidine.
What this interaction means in plain words
Brimonidine and Triclofos have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depression from alpha-2 agonism and the sedative action of trichloroethanol, the active metabolite of triclofos.
What to do
Monitor for excess sedation, especially in children. Avoid giving brimonidine to infants receiving triclofos.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Triclofos?
MediHelp rates the interaction as minor. Brimonidine and Triclofos have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triclofos is a sedative-hypnotic, and brimonidine can cause drowsiness, so sedation may be somewhat increased. Systemic exposure from eye drops is low, so the effect is usually small, though children are more sensitive to brimonidine.
How serious is the interaction between Brimonidine and Triclofos?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, especially in children. Avoid giving brimonidine to infants receiving triclofos.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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