Drug interactions
Brivaracetam + Clonazepam
Severity: Moderate
Brivaracetam and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs commonly cause somnolence, dizziness and fatigue, and these effects may be additive. This is often tolerable but can affect alertness and coordination.
What this interaction means in plain words
Brivaracetam and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Clonazepam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through GABA-A modulation and SV2A binding with sedative adverse effects.
What to do
Monitor for sedation, dizziness and falls, and adjust doses if symptoms are troublesome. Advise caution with driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Clonazepam?
MediHelp rates the interaction as moderate. Brivaracetam and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs commonly cause somnolence, dizziness and fatigue, and these effects may be additive. This is often tolerable but can affect alertness and coordination.
How serious is the interaction between Brivaracetam and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and falls, and adjust doses if symptoms are troublesome. Advise caution with driving.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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