Drug interactions
Brivaracetam + Lorazepam
Severity: Moderate
Brivaracetam and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause somnolence, dizziness and fatigue, and used together these effects can be additive. This is relevant to driving and fall risk.
What this interaction means in plain words
Brivaracetam and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through SV2A modulation and GABA-A potentiation.
What to do
Monitor for sedation and cognitive slowing, and titrate doses gradually. Advise patients to avoid driving until the effects are known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Lorazepam?
MediHelp rates the interaction as moderate. Brivaracetam and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause somnolence, dizziness and fatigue, and used together these effects can be additive. This is relevant to driving and fall risk.
How serious is the interaction between Brivaracetam and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive slowing, and titrate doses gradually. Advise patients to avoid driving until the effects are known.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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