Drug interactions
Brivaracetam + Mavacamten
Severity: Moderate
Brivaracetam and Mavacamten: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brivaracetam is a weak CYP2C19 inhibitor and may raise mavacamten levels, which could increase the risk of excessive reduction in left ventricular ejection fraction and heart failure symptoms.
What this interaction means in plain words
Brivaracetam and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP2C19-mediated mavacamten metabolism by brivaracetam.
What to do
Monitor LVEF and clinical status when starting or stopping brivaracetam and adjust mavacamten dose per echocardiographic guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brivaracetam and Mavacamten, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brivaracetam
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Brivaracetam with Mavacamten?
MediHelp rates the interaction as moderate. Brivaracetam and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brivaracetam is a weak CYP2C19 inhibitor and may raise mavacamten levels, which could increase the risk of excessive reduction in left ventricular ejection fraction and heart failure symptoms.
How serious is the interaction between Brivaracetam and Mavacamten?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LVEF and clinical status when starting or stopping brivaracetam and adjust mavacamten dose per echocardiographic guidance.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
