Drug interactions
Brivaracetam + Morphine
Severity: Moderate
Brivaracetam and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brivaracetam commonly causes somnolence and dizziness, which may add to opioid-related sedation. No important pharmacokinetic interaction is expected, so the concern is additive CNS effects.
What this interaction means in plain words
Brivaracetam and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and SV2A-mediated antiseizure activity.
What to do
Monitor for sedation and dizziness when starting or increasing either drug. Reduce doses if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Morphine?
MediHelp rates the interaction as moderate. Brivaracetam and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brivaracetam commonly causes somnolence and dizziness, which may add to opioid-related sedation. No important pharmacokinetic interaction is expected, so the concern is additive CNS effects.
How serious is the interaction between Brivaracetam and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness when starting or increasing either drug. Reduce doses if impairment occurs.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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