Drug interactions
Brivaracetam + Nortriptyline
Severity: Minor
Brivaracetam and Nortriptyline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, dizziness and impaired coordination, so combined use may increase CNS depression. Tricyclics may also lower the seizure threshold, potentially working against brivaracetam.
What this interaction means in plain words
Brivaracetam and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brivaracetam belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; tricyclics may lower seizure threshold.
What to do
Counsel patients about sedation and driving, and monitor seizure control after starting nortriptyline.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Nortriptyline?
MediHelp rates the interaction as minor. Brivaracetam and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause drowsiness, dizziness and impaired coordination, so combined use may increase CNS depression. Tricyclics may also lower the seizure threshold, potentially working against brivaracetam.
How serious is the interaction between Brivaracetam and Nortriptyline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about sedation and driving, and monitor seizure control after starting nortriptyline.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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