Drug interactions
Budesonide + Cyclosporin
Severity: Moderate
Budesonide and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can increase systemic budesonide exposure, which may lead to corticosteroid effects such as Cushingoid features and adrenal suppression. This is more relevant with oral budesonide or long-term use.
What this interaction means in plain words
Budesonide and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Cyclosporin belongs to Miscellaneous.
Why it happens
Cyclosporine inhibits CYP3A4 and P-glycoprotein, reducing budesonide first-pass metabolism and clearance.
What to do
Monitor for signs of systemic corticosteroid excess and consider reducing the budesonide dose or using an alternative if long-term combination is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Budesonide and Cyclosporin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Cyclosporin?
MediHelp rates the interaction as moderate. Budesonide and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can increase systemic budesonide exposure, which may lead to corticosteroid effects such as Cushingoid features and adrenal suppression. This is more relevant with oral budesonide or long-term use.
How serious is the interaction between Budesonide and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of systemic corticosteroid excess and consider reducing the budesonide dose or using an alternative if long-term combination is needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
