Drug interactions
Budesonide + Glyburide-metformin
Severity: Minor
Budesonide and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can raise blood glucose and reduce the effect of antidiabetic drugs. Systemic exposure to budesonide is lower, especially for inhaled or locally acting forms, so the effect is usually modest.
What this interaction means in plain words
Budesonide and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide belongs to Respiratory; Glyburide-metformin belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic gluconeogenesis oppose the effects of glyburide and metformin.
What to do
Monitor blood glucose when starting or increasing budesonide, particularly oral formulations or high doses, and adjust therapy if hyperglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Glyburide-metformin?
MediHelp rates the interaction as minor. Budesonide and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids can raise blood glucose and reduce the effect of antidiabetic drugs. Systemic exposure to budesonide is lower, especially for inhaled or locally acting forms, so the effect is usually modest.
How serious is the interaction between Budesonide and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or increasing budesonide, particularly oral formulations or high doses, and adjust therapy if hyperglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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