Drug interactions
Budesonide + Hydrochlorothiazide-valsartan
Severity: Minor
Budesonide and Hydrochlorothiazide-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and corticosteroids both promote potassium loss, so combined use can add to hypokalemia. The risk is greater with systemic exposure than with locally acting budesonide formulations.
What this interaction means in plain words
Budesonide and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide belongs to Respiratory; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from thiazide action and corticosteroid mineralocorticoid effect.
What to do
Monitor serum potassium, especially with oral or high-dose budesonide. Replace potassium if levels fall.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as minor. Budesonide and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide and corticosteroids both promote potassium loss, so combined use can add to hypokalemia. The risk is greater with systemic exposure than with locally acting budesonide formulations.
How serious is the interaction between Budesonide and Hydrochlorothiazide-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially with oral or high-dose budesonide. Replace potassium if levels fall.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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