Drug interactions
Budesonide + Istradefylline
Severity: Minor
Budesonide and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily istradefylline can raise exposure to CYP3A4 and P-glycoprotein substrates, which may increase systemic budesonide levels. At 20 mg daily this effect is not expected.
What this interaction means in plain words
Budesonide and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide belongs to Respiratory; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at higher doses inhibits CYP3A4 and P-glycoprotein, reducing budesonide clearance.
What to do
Monitor for corticosteroid adverse effects if the 40 mg dose is used with oral budesonide; consider a budesonide dose reduction if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Budesonide
Other interactions of Istradefylline
Frequently asked questions
Can I take Budesonide with Istradefylline?
MediHelp rates the interaction as minor. Budesonide and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg daily istradefylline can raise exposure to CYP3A4 and P-glycoprotein substrates, which may increase systemic budesonide levels. At 20 mg daily this effect is not expected.
How serious is the interaction between Budesonide and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects if the 40 mg dose is used with oral budesonide; consider a budesonide dose reduction if they appear.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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