Drug interactions
Budesonide + Larotrectinib
Severity: Minor
Budesonide and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a modest inhibitor in vitro, so it may raise exposure to budesonide, which relies heavily on CYP3A4 for first-pass clearance. Higher systemic budesonide levels could increase corticosteroid adverse effects such as adrenal suppression with prolonged use.
What this interaction means in plain words
Budesonide and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide belongs to Respiratory; Larotrectinib belongs to Oncology.
Why it happens
Possible inhibition of CYP3A4-mediated budesonide metabolism; the effect is predicted rather than well characterized.
What to do
Watch for signs of corticosteroid excess during prolonged co-therapy, and consider reducing the budesonide dose if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Budesonide
Other interactions of Larotrectinib
Frequently asked questions
Can I take Budesonide with Larotrectinib?
MediHelp rates the interaction as minor. Budesonide and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a modest inhibitor in vitro, so it may raise exposure to budesonide, which relies heavily on CYP3A4 for first-pass clearance. Higher systemic budesonide levels could increase corticosteroid adverse effects such as adrenal suppression with prolonged use.
How serious is the interaction between Budesonide and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of corticosteroid excess during prolonged co-therapy, and consider reducing the budesonide dose if they appear.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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