Drug interactions
Chloramphenicol + Larotrectinib
Severity: Major
Chloramphenicol and Larotrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and its exposure rises with inhibitors. This may increase hepatotoxicity, neurotoxicity such as dizziness, and other adverse effects.
What this interaction means in plain words
Chloramphenicol and Larotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Larotrectinib belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4, decreasing larotrectinib clearance.
What to do
Prefer a non-inhibiting antibiotic. If unavoidable, reduce larotrectinib dose by about half per labeling and monitor liver tests and neurologic effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Larotrectinib
Frequently asked questions
Can I take Chloramphenicol with Larotrectinib?
MediHelp rates the interaction as major. Chloramphenicol and Larotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Larotrectinib is a CYP3A4 substrate and its exposure rises with inhibitors. This may increase hepatotoxicity, neurotoxicity such as dizziness, and other adverse effects.
How serious is the interaction between Chloramphenicol and Larotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inhibiting antibiotic. If unavoidable, reduce larotrectinib dose by about half per labeling and monitor liver tests and neurologic effects.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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