Drug interactions
Budesonide + Metyrapone
Severity: Moderate
Budesonide and Metyrapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metyrapone blocks cortisol synthesis and is used in diagnostic tests and in Cushing's syndrome. Exogenous glucocorticoids suppress ACTH and cortisol and can confound test results, and they counteract the intended therapeutic effect.
What this interaction means in plain words
Budesonide and Metyrapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Metyrapone belongs to Endocrine.
Why it happens
Pharmacodynamic opposition: exogenous corticosteroid suppresses the HPA axis and supplies glucocorticoid activity that metyrapone is meant to reduce.
What to do
Avoid giving budesonide on the day of a metyrapone stimulation test if possible, and interpret results in light of steroid exposure. In treatment, monitor cortisol control and adjust dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Metyrapone
- Metyrapone + Pacritinib Major
- Cortisone + Metyrapone Moderate
- Cyproheptadine + Metyrapone Moderate
- Deflazacort + Metyrapone Moderate
- Desogestrel-ethinyl estradiol + Metyrapone Moderate
- Dexamethasone + Metyrapone Moderate
Frequently asked questions
Can I take Budesonide with Metyrapone?
MediHelp rates the interaction as moderate. Budesonide and Metyrapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metyrapone blocks cortisol synthesis and is used in diagnostic tests and in Cushing's syndrome. Exogenous glucocorticoids suppress ACTH and cortisol and can confound test results, and they counteract the intended therapeutic effect.
How serious is the interaction between Budesonide and Metyrapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving budesonide on the day of a metyrapone stimulation test if possible, and interpret results in light of steroid exposure. In treatment, monitor cortisol control and adjust dosing.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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