Drug interactions
Deflazacort + Metyrapone
Severity: Moderate
Deflazacort and Metyrapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metyrapone blocks cortisol synthesis and is used diagnostically and therapeutically, so exogenous glucocorticoids oppose its effect. Deflazacort also suppresses ACTH and may interfere with the interpretation of the metyrapone test.
What this interaction means in plain words
Deflazacort and Metyrapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Metyrapone belongs to Endocrine.
Why it happens
Exogenous corticosteroid suppresses the pituitary-adrenal axis and provides glucocorticoid activity that offsets metyrapone's inhibition of 11-beta-hydroxylase.
What to do
Avoid corticosteroids before a metyrapone stimulation test unless adrenal insufficiency risk requires them. When metyrapone is used therapeutically, monitor cortisol and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Metyrapone
- Metyrapone + Pacritinib Major
- Budesonide + Metyrapone Moderate
- Cortisone + Metyrapone Moderate
- Cyproheptadine + Metyrapone Moderate
- Desogestrel-ethinyl estradiol + Metyrapone Moderate
- Dexamethasone + Metyrapone Moderate
Frequently asked questions
Can I take Deflazacort with Metyrapone?
MediHelp rates the interaction as moderate. Deflazacort and Metyrapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metyrapone blocks cortisol synthesis and is used diagnostically and therapeutically, so exogenous glucocorticoids oppose its effect. Deflazacort also suppresses ACTH and may interfere with the interpretation of the metyrapone test.
How serious is the interaction between Deflazacort and Metyrapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid corticosteroids before a metyrapone stimulation test unless adrenal insufficiency risk requires them. When metyrapone is used therapeutically, monitor cortisol and clinical response.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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