Drug interactions
Budesonide + Naproxen
Severity: Moderate
Budesonide and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concomitant corticosteroid and NSAID use increases the risk of peptic ulceration and upper GI bleeding. The risk is greater with prolonged use, higher doses and in older patients.
What this interaction means in plain words
Budesonide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Naproxen belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effects: NSAID prostaglandin inhibition reduces mucosal protection while corticosteroids impair mucosal repair.
What to do
Use the lowest effective naproxen dose for the shortest time and add a proton pump inhibitor in at-risk patients. Monitor for melena, hematemesis or anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Budesonide with Naproxen?
MediHelp rates the interaction as moderate. Budesonide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concomitant corticosteroid and NSAID use increases the risk of peptic ulceration and upper GI bleeding. The risk is greater with prolonged use, higher doses and in older patients.
How serious is the interaction between Budesonide and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective naproxen dose for the shortest time and add a proton pump inhibitor in at-risk patients. Monitor for melena, hematemesis or anemia.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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