Drug interactions
Budesonide + Nelfinavir
Severity: Moderate
Budesonide and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and can raise systemic budesonide levels. This increases the risk of corticosteroid adverse effects such as Cushingoid features and adrenal suppression, particularly with prolonged use.
What this interaction means in plain words
Budesonide and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Nelfinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 by nelfinavir reduces first-pass and systemic clearance of budesonide.
What to do
Monitor for signs of hypercortisolism and consider limiting the duration or using a corticosteroid less dependent on CYP3A4, such as beclomethasone, for long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Budesonide with Nelfinavir?
MediHelp rates the interaction as moderate. Budesonide and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and can raise systemic budesonide levels. This increases the risk of corticosteroid adverse effects such as Cushingoid features and adrenal suppression, particularly with prolonged use.
How serious is the interaction between Budesonide and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of hypercortisolism and consider limiting the duration or using a corticosteroid less dependent on CYP3A4, such as beclomethasone, for long-term therapy.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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