Drug interactions
Avanafil + Nelfinavir
Severity: Contraindicated
Avanafil and Nelfinavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and can significantly increase avanafil exposure. Severe hypotension, syncope, visual effects and priapism may follow.
What this interaction means in plain words
Avanafil and Nelfinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Nelfinavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition decreases avanafil metabolism.
What to do
Do not coadminister; consider alternative therapy for erectile dysfunction.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Avanafil with Nelfinavir?
MediHelp rates the interaction as contraindicated. Avanafil and Nelfinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nelfinavir inhibits CYP3A4 and can significantly increase avanafil exposure. Severe hypotension, syncope, visual effects and priapism may follow.
How serious is the interaction between Avanafil and Nelfinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; consider alternative therapy for erectile dysfunction.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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