Drug interactions
Budesonide + Nilotinib
Severity: Moderate
Budesonide and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and P-glycoprotein and may increase budesonide exposure, raising the risk of systemic corticosteroid effects. Nilotinib also prolongs the QT interval, but that is not changed by budesonide.
What this interaction means in plain words
Budesonide and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP3A4 and P-glycoprotein, reducing budesonide clearance.
What to do
Monitor for Cushingoid features, hyperglycemia and adrenal suppression, particularly with oral budesonide or prolonged use. Reduce the budesonide dose if signs of excess appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Budesonide and Nilotinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Budesonide
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Budesonide with Nilotinib?
MediHelp rates the interaction as moderate. Budesonide and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and P-glycoprotein and may increase budesonide exposure, raising the risk of systemic corticosteroid effects. Nilotinib also prolongs the QT interval, but that is not changed by budesonide.
How serious is the interaction between Budesonide and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushingoid features, hyperglycemia and adrenal suppression, particularly with oral budesonide or prolonged use. Reduce the budesonide dose if signs of excess appear.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
