Drug interactions
Budesonide + Primidone
Severity: Moderate
Budesonide and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolised to phenobarbital and acts as a CYP3A4 inducer, which may reduce budesonide exposure and efficacy.
What this interaction means in plain words
Budesonide and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Primidone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by primidone and its phenobarbital metabolite increases budesonide clearance.
What to do
Monitor for reduced response to budesonide and adjust the dose or use an alternative if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Budesonide with Primidone?
MediHelp rates the interaction as moderate. Budesonide and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolised to phenobarbital and acts as a CYP3A4 inducer, which may reduce budesonide exposure and efficacy.
How serious is the interaction between Budesonide and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to budesonide and adjust the dose or use an alternative if needed.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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