Drug interactions
Buprenorphine + Cyclobenzaprine
Severity: Moderate
Buprenorphine and Cyclobenzaprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is structurally related to tricyclic antidepressants and is sedating, so it can add to buprenorphine's CNS depression. Both drugs also carry some serotonergic potential, so serotonin syndrome is a theoretical concern.
What this interaction means in plain words
Buprenorphine and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Cyclobenzaprine belongs to Musculoskeletal.
Why it happens
Additive CNS depression, with possible additive serotonergic effects.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression. Watch for agitation, tremor, hyperthermia or clonus suggesting serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buprenorphine with Cyclobenzaprine?
MediHelp rates the interaction as moderate. Buprenorphine and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is structurally related to tricyclic antidepressants and is sedating, so it can add to buprenorphine's CNS depression. Both drugs also carry some serotonergic potential, so serotonin syndrome is a theoretical concern.
How serious is the interaction between Buprenorphine and Cyclobenzaprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Watch for agitation, tremor, hyperthermia or clonus suggesting serotonin toxicity.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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