Drug interactions
Buprenorphine + Cyclophosphamide
Severity: Minor
Buprenorphine and Cyclophosphamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclophosphamide is not an established CYP3A4 inhibitor, so a significant effect on buprenorphine is unlikely. Any interaction is theoretical.
What this interaction means in plain words
Buprenorphine and Cyclophosphamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buprenorphine belongs to Musculoskeletal; Cyclophosphamide belongs to Oncology.
Why it happens
Possible competition at CYP3A4; not established clinically.
What to do
No specific action is needed beyond routine monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Buprenorphine with Cyclophosphamide?
MediHelp rates the interaction as minor. Buprenorphine and Cyclophosphamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclophosphamide is not an established CYP3A4 inhibitor, so a significant effect on buprenorphine is unlikely. Any interaction is theoretical.
How serious is the interaction between Buprenorphine and Cyclophosphamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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